The AAFP guideline and pocket card contains clinical recommendations for primary care physicians to pharmacologically manage atrial fibrillation based on the available evidence. Management options for AF involve rate control, rhythm control, and/or prevention of thromboembolic events. Prior to initiating treatment, clinicians should discuss the benefits and harms of the different medications, including potential medication cost, lifestyle modifications, and risk of bleeding with anticoagulation. Tools for risk assessment and shared decision making are available.