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The benefit of fluoride-containing toothpaste arises from its topical effect on dental enamel by interrupting enamel demineralization caused by bacterial acids and enhancing remineralization of the enamel surface. Anti-caries (anti-cavities) benefit begins with eruption of the first primary tooth. Brushing with nonfluoridated toothpaste provides no anti-caries benefit. Use of recommended amounts of fluoride toothpaste minimizes risks of fluorosis, a whitish discoloration of enamel.