Drugs	Time to peak concentration	Absolute bioavailability	Administration with food: area under the curve	Elimination half-life	Elimination altered renally	Elimination altered hepatical ly	Protein binding
Losartan (Cozaar)	1 hour for losartan, 3 to 4 hours for its active metabolite*	Approximately 33%	Decreased 10%	2 hours for losartan, 6 to 9 hours for its active metabolite*	No	Yes	98.7 %
Valsartan (Diovan)	2 to 4 hours	Approximately 25%	Decreased 40% to 50%	6 hours	No	Yes	95 %
Irbesartan (Avapro)	1.5 to 2 hours	60% to 80%	No effect	11 to 15 hours	No	No	90 %
Candesartan (Atacand)†	3 to 4 hours	Approximately 15%	No effect	9 hours	No	Yes	>99 %
Telmisartan (Micardis)	0.5 to 1 hour	Approximately 42% to 58%	Decreased 6% to 20%	24 hours	No	Yes	99.5 %