Option 1 (daily treatment)	Administer isoniazid (INH), rifampin (Rifadin), pyrazinamide and ethambutol (Myambutol) daily for 2 months; then administer isoniazid and rifampin daily or two to three times a week (only by directly observed therapy) for susceptible isolates.
Option 2 (twice-weekly treatment)	Administer isoniazid, rifampin, pyrazinamide and ethambutol daily for 2 weeks; then administer the same drugs two times a week for 6 weeks (only by directly observed therapy); subsequently administer isoniazid and rifampin two times a week for 4 months (only by directly observed therapy) for susceptible isolates.
Option 3 (thrice-weekly treatment)	Administer isoniazid, rifampin, pyrazinamide and ethambutol three times a week for 6 months (only by directly observed therapy).