Drugs	Possible regimens			HIV therapy
Isoniazid (INH), rifampin (Rifadin), pyrazinamide and either ethambutol (Myambutol) or streptomycin	Six-month rifampin-based treatments*:			The concomitant use of protease inhibitors or nonnucleoside reverse transcriptase inhibitors is contraindicated. The use of streptomycin is contraindicated in pregnant women.
			Administer all four drugs daily for 2 months; then continue rifampin and isoniazid daily or two times a week for 4 months.
			or
			Administer all four drugs daily for 2 weeks and then two to three times a week for 6 weeks; continue rifampin and isoniazid two or three times a week for 4 months.
			or
			Administer all four drugs three times a week for 6 months.
Isoniazid, rifabutin (Mycobutin), pyrazinamide and ethambutol	Six-month rifabutin-based treatments*:			The rifabutin-based regimens may be used in patients who are being treated with protease inhibitors or nonnucleoside reverse transcriptase inhibitors. Patients should be closely monitored for toxicity. With some agents, the rifabutin dosage may need to be reduced.
			Administer all four drugs daily for 2 months; then continue rifabutin and isoniazid daily or two times a week for 4 months.
			or
			Administer all four drugs daily for 2 weeks and then two times a week for 6 weeks; continue rifabutin and isoniazid two times a week for 4 months.
Isoniazid, streptomycin, pyrazinamide and ethambutol	Nine-month streptomycin-based treatments†:			The streptomycin-based regimens may be used in patients who are being treated with protease inhibitors or nonnucleoside reverse transcriptase inhibitors. The use of streptomycin is contraindicated in pregnant women.
			Administer all four drugs daily for 2 months; then continue streptomycin, isoniazid and pyrazinamide two or three times a week for 7 months.
			or
			Administer all four drugs daily for 2 weeks and then two or three times a week for 6 weeks; continue treatment two or three times a week for 7 months.