Medication	Mechanism of effect	Side effects	Dosage	Cost
Sibutramine (Meridia)	Reuptake inhibitor of serotonin, norepinephrine and dopamine	Elevated blood pressure, tachycardia, headache, insomnia, constipation, dry mouth	10 mg daily initially; can increase to 15 mg daily after 4 weeks in nonresponders	$ 87*
Orlistat (Xenical)	Reversible lipase inhibitor	Fecal incontinence, oily spotting, flatulence, vitamin malabsorption	120 mg three times daily with meals	119†