Outpatients
	Generally preferred: doxycycline (Vibramycin), a macrolide* or a fluoroquinolone†
	Modifying factors:
		Suspected penicillin-resistant Streptococcus pneumoniae: fluoroquinolone†
	Suspected aspiration: amoxicillin/clavulanate potassium (Augmentin)
	Elderly, debilitated patients: some authorities prefer a fluoroquinolone as first choice
Hospitalized patients
	General medical ward
		Generally preferred: an extended-spectrum cephalosporin with a macrolide,* or a beta-lactam/beta-lactamase inhibitor combined with a macrolide, or a fluoroquinolone alone
Hospitalized in the intensive care unit with serious pneumonia
	Generally preferred: erythromycin, azithromycin (Zithromax) or a fluoroquinolone† plus cefotaxime (Claforan), ceftriaxone (Rocephin) or a beta-lactam/beta-lactamase inhibitor‡
	Modifying factors
		Structural diseases of the lung: antipseudomonal penicillin, a carbapenem or cefepime (Maxipime) plus a fluoroquinolone†
		Penicillin allergy: a fluoroquinolone†, with or without clindamycin (Cleocin)
		Suspected aspiration: a fluoroquinolone§, with or without clindamycin, metronidazole (Flagyl) or a beta-lactam/beta-lactamase inhibitor§ alone