AgentDosageComments on drug classComments on specific drugCost (generic)*
ACE inhibitors
Benazepril (Lotensin)20 to 40 mg daily, single dose or two divided dosesStart with low dose and titrate up$27
Captopril (Capoten)75 to 150 mg daily in three dosesRisk of neutropenia87 (58.50 to 68)
Enalapril (Vasotec)5 to 20 mg daily in divided dosesCaution with creatinine level > 3 mg per dL (265 mmol per L); do not use in pregnancy53 (46 to 53)
Fosinopril (Monopril)20 to 40 daily, single dose29
Lisinopril (Zestril, Prinivil)5 to 20 mg daily, single doseRisk of neutropenia28
Moexipril (Univasc)7.5 to 30 daily, one hour before meals, single or two divided doses22
Quinapril (Accupril)20 to 40 mg daily in two divided dosesCan cause angioedema66
Ramipril (Altace)5 mg twice daily67
Trandolapril (Mavik)1 to 4 mg daily24
Angiotensin receptor antagonists
Losartan (Cozaar)25 to 100 mg daily, single or divided dosesPregnancy class C41
Valsartan (Diovan)80 to 320 daily, single doseHypotension with volume depletion41
Irbesartan (Avapro)150 to 300 daily, single doseMay precipitate acute renal failure in patients with renal impairment39
Candesartan (Atacand)8 to 32 mg daily, single or two divided dosesBlack patients have less response39
Telmisartan (Micardis)20 to 80 mg daily, single dosePossible increase in liver enzymesIncreases concentration of digoxin [ corrected]40
Beta blockers
Carvedilol (Coreg)3.125 mg twice daily for two weeks, slowly increase to maximum 25 mg twice daily (< 85 kg [187 lb]) or 50 mg twice daily (> 85 kg)Contraindicated in patients with dizziness, bradycardia or asthma, and in patients with second- or third-degree AV block97
Metoprolol (Lopressor, Toprol XL)100 to 400 mg daily in a single dose (Toprol XL) or two divided doses (Lopressor)Potentiates effects of calcium channel blockersMetoprolol increases effect of phenothiazines27 (Toprol XL) 46 (31 to 33; Lopressor)
Cardiac glycoside
Digoxin (Lanoxin)0.125 to 0.25 mg once dailySmall therapeutic window6 (2 to 7)
Diuretics
Furosemide (Lasix)20 to 80 mg daily, single or two divided doses6 (3 to 4)
Spironolactone (Aldactone)25 to 50 mg daily, single dose or two divided doses16 (2 to 6)