Drug and delivery system		Initial dosage	Maintenance dosage	Duration of therapy	Approximate cost*
Nicotine replacement
	Patch (Habitrol, Nicoderm CQ, Nicotrol)	One patch per day (21 mg, 14 mg, or 7 mg, depending on degree of nicotine dependence)	Taper to next lowest patch strength in 4 to 6 weeks.	8 to 12 weeks	$89 to 124
	Gum, 4-mg strength (Nicorette)	10 to 15 pieces per day	Five to eight pieces per day	8 weeks to 5 years	73
	Inhaler (Nicotrol Inhaler)	Four inhalers per day	Four inhalers per day, with gradual tapering of use	8 to 12 weeks	123
	Nasal spray (Nicotrol NS)	Four sprays per hour	Eight to 80 sprays per day, with gradual tapering of use	8 to 12 weeks	$170 to 255 (four to six bottles)
Bupropion (Zyban)		150 mg per day for 3 days	150 mg twice daily	8 to 12 weeks	96