Investigators	End points	Results
MacKay24	Various	Some studies showed statistical differences with antibiotic therapy, but there was no clinical significance.
Fahey, et al.25	Productive cough, lack of improvement, side effects	Antibiotic therapy did not improve cough or clinical status, and patients had more side effects than those who did not take antibiotics.
Smucny, et al.26	Cough, productive cough, subjective ill feeling, activity limitations, less likely to show no improvement on follow-up assessment	Antibiotic therapy resulted in shorter duration of cough and decreased likelihood of continued cough.
Bent, et al.27	Cough, sputum production, days lost from work	Antibiotic therapy decreased duration of cough by 12 hours.
Smucny, et al.28	Cough, improved assessment, pulmonary findings, subjective ill feeling, activity limitations	Antibiotic-treated patients were less likely to have cough, be unimproved, or have abnormal pulmonary findings; they also had shorter duration of cough and subjective ill feeling.