| Drug | Omeprazole (Prilosec) | Lansoprazole (Prevacid) | Pantoprazole (Protonix) | Rabeprazole (Aciphex) |
|---|---|---|---|---|
| Carbamazepine (Tegretol) | ↓Metabolism | Unknown | None | Unknown |
| Clarithromycin (Biaxin) | * | None | Unknown | Unknown |
| Diazepam (Valium) | ↓ Metabolism | None | None | None |
| Digoxin | ↑ Absorption | Unknown | ↑ Absorption | ↑ Absorption |
| Ketoconazole (Nizoral) | ↓ Absorption | ↓ Absorption | Unknown | ↓ Absorption |
| Methotrexate | ↓ Renal excretion | Unknown | Unknown | Unknown |
| Nifedipine (Procardia) | ↑ Absorption | Unknown | ↑ Absorption | Unknown |
| Oral contraceptives | None | None | None | Unknown |
| Phenytoin (Dilantin) | ↓ Metabolism | None | None | None |
| Warfarin (Coumadin) | ↓ Metabolism | None | None | None |
| Theophylline | None | ↑ Metabolism | None | None |