| Rheumatoid arthritis | Keratoconjunctivitis sicca, scleritis, episcleritis, keratitis, ulcerative keratitis, choroiditis, retinal vasculitis, episcleral nodules, retinal detachments, macular edema |
| Juvenile rheumatoid arthritis | Uveitis |
| Sjögren's syndrome | Keratoconjunctivitis sicca |
| Ankylosing spondylitis | Uveitis |
| Reiter's syndrome | Conjunctivitis, uveitis, keratitis |
| Enteropathic arthritis | Uveitis, episcleritis, peripheral ulcerative keratitis |
| Psoriatic arthritis | Uveitis, conjunctivitis, keratitis |
| Systemic lupus erythematosus | Keratoconjunctivitis sicca, conjunctivitis, uveitis, episcleritis, scleritis, keratitis, retinal hemorrhages, retinal vasculitis, proliferative retinopathy, optic neuritis, ischemic optic neuropathy, hemianopia, amaurosis, internuclear ophthalmoplegia, pupillary abnormalities, oculomotor abnormalities, visual hallucinations |
| Multiple sclerosis | Afferent: optic neuritis, retrobulbar neuritis, visual field defects |
| Efferent: internuclear ophthalmoplegia, dysmetria, nystagmus, cranial nerve palsies |
| Giant cell arteritis | Amaurosis fugax, diplopia, vision loss |
| Graves' disease | Proptosis/exophthalmos, lid lag and retraction, keratitis, decreased visual acuity, reduced visual fields, relative afferent pupillary defect, loss of color vision |
| Myasthenia gravis | Diplopia, eyelid ptosis |
| Sarcoidosis | Uveitis, conjunctival nodules, cranial nerve palsies, enlarged lacrimal glands, optic neuropathy |
| Wegener's granulomatosis | Proptosis/exophthalmos, orbital cellulitis, uveitis, corneal ulcers, optic neuropathy |
| Behçet's syndrome | Uveitis, hypopyon |
| Antiphospholipid syndrome | Vaso-occlusive retinopathy, ischemic optic neuropathy |
| Polyarteritis nodosa | Episcleritis, scleritis, optic neuropathy |
| Takayasu's arteritis | Vaso-occlusive retinopathy, ischemic optic neuropathy, cataracts |
| Dermatomyositis | Eyelid/conjunctival edema, retinopathy, uveitis |