Drug action/classAgentStrength (%)Unit sizeDosing intervalPregnancy category*Cost (generic)
Decrease aqueous production: beta blockers, nonspecificLevobunolol (Betagan Liquifilm)0.25010 mLTwice a dayC$ 48.50 (27.00)
Levobunolol0.5005 mLOnce or twice a dayC29.50 (9.50)
Carteolol (Ocupress)1.00010 mLTwice a dayC56.00 (37.00)
Metipranolol (Optipranolol)0.30010 mLTwice a dayC30.00 (27.00)
Timolol maleate (Timoptic)0.25010 mLTwice a dayC36.00 (11.00)
Timolol maleate0.50010 mLTwice a dayC43.00 (12.00)
Timolol maleate (XE: solution or gel)0.2505 mLOnce a dayC29.00 (26.00)
Timolol maleate (XE: solution or gel)0.5005 mLOnce a dayC34.50 (31.00)
Decrease aqueous production: beta blockers, relatively specificBetaxolol (Betoptic)0.50010 mLTwice a dayC58.00 (NA)
Decrease aqueous production: carbonic anhydrase inhibitorsDorzolamide (Trusopt)2.00010 mLThree times a dayC54.00 (NA)
Brinzolamide (Azopt)1.00010 mLThree times a dayC53.00 (NA)
Decrease aqueous production, may increase outflow: alpha agonistsApraclonidine (Iopidine)0.5005 mLThree times a dayC57.50 (NA)
Apraclonidine1.00024 0.1-mL unit-dose packetsThree times a dayC229.00 (NA)
Brimonidine tartrate (Alphagan)0.20010 mLThree times a dayB72.50 (NA)
Brimonidine tartrate (purite preserved; Alphagan P)0.15015 mLThree times a dayB95.00 (NA)
Increase aqueous outflow: prostaglandin analogsLatanoprost (Xalatan)0.0052.5 mLOnce a dayC50.00 (NA)
Bimatoprost (Lumigan)0.0305 mLOnce a dayC100.00 (NA)
Travoprost (Travatan)0.0042.5 mLOnce a dayC45.50 (NA)
Unoprostone (Rescula)0.1505 mLTwice a dayC47.00 (NA)
Increase aqueous outflow: parasympathomimeticPilocarpine (Pilocar)1.00015 mLThree to four times a dayC5.00 (3.50)
Pilocarpine (Pilocar)2.00015 mLThree to four times a dayC7.00 (4.50)
Increase aqueous outflow: sympathomimeticDipivefrin (Propine)0.10010 mLTwice a dayB45.50 (10.00)
Combination medicationsDorzolamide and timolol maleate (Cosopt)2/0.510 mLTwice a dayC92.00 (NA)