| Atenolol (Tenormin) | MAOIs, tricyclic antidepressants, trazodone (Desyrel), venlafaxine (Effexor) | |
| Caffeine | Bupropion (Wellbutrin), fluvoxamine (Luvox), MAOIs, venlafaxine | |
| Captopril (Capoten) | MAOIs, tricyclic antidepressants, trazodone | |
| Codeine | Fluoxetine (Prozac), fluvoxamine, paroxetine (Paxil), tricyclic antidepressants, trazodone | MAOIs (hypertensive crisis) |
| Digoxin | Tricyclic antidepressants | |
| Nifedipine (Procardia) | MAOIs, nefazodone (Serzone), tricyclic antidepressants | |
| Phenytoin (Dilantin) | Fluoxetine, fluvoxamine, sertraline (Zoloft) | |
| Theophylline | Fluoxetine, fluvoxamine, MAOIs | |
| Tramadol (Ultram) | Citalopram (Celexa), fluoxetine, fluvoxamine, mirtazapine (Remeron), nefazodone, paroxetine, sertraline, tricyclic antidepressants, trazodone, venlafaxine | MAOIs (potentiate seizure risk) |
| Tricyclic antidepressants | Bupropion, citalopram, fluoxetine, fluvoxamine, mirtazapine, paroxetine, sertraline, trazodone, venlafaxine | MAOIs, tricyclic antidepressants (serotonin syndrome) |
| Warfarin (Coumadin) | Citalopram, fluoxetine, fluvoxamine, MAOIs, mirtazapine, paroxetine, sertraline, venlafaxine | |