| Mild disease and no recent antibiotic use | | | |
| Amoxicillin-clavulanate potassium (Augmentin)‡ | 500 mg every 8 hours, 875 mg every 12 hours§ | 91 | $83.96 to 112.08 |
| High dose (Augmentin XR) | 2,000 mg every 12 hours§ | — | 112.08 |
| Amoxicillin (Amoxil) | 500 mg every 8 hours, 875 mg every 12 hours | 88 | 7.35 to 8.77 (8.25) |
| High dose | 1,000 mg every 8 hours | — | 14.70 to 17.54 (16.50) |
| Cefpodoxime (Vantin)‡ | 200 mg every 12 hours | 87 | 118.48 |
| Cefuroxime (Ceftin)‡ | 250 mg or 500 mg every 12 hours | 85 | 108.53, 197.75 |
| Cefdinir (Omnicef)‡ | 300 mg every 24 hours | 83 | 44.66 |
| If beta-lactam allergic: | | | |
| TMP-SMX DS (Bactrim DS, Septra) | 160 to 800 mg every 12 hours | 83 | 6.64 to 27.76 (38.85) |
| Doxycycline (Vibramycin) | 100 mg every 12 hours | 81 | 5.00 to 27.36 (97.13) |
| Azithromycin (Zithromax) | 500 mg on day 1, 250 mg on days 2 through 5 | 77 | 47.44 |
| Clarithromycin (Biaxin) | 250 mg or 500 mg every 12 hours | 77 | 90.22, 90.22 |
| Telithromycin (Ketek) | 800 mg every 24 hours | 77 | — |
| Moderate disease or recent antibiotic use | | | |
| Gatifloxacin (Tequin) | 400 mg every 24 hours | 92 | 95.68 |
| Levofloxacin (Levaquin) | 500 mg every 24 hours | 92 | 101.47 |
| Moxifloxacin (Avelox) | 400 mg every 24 hours | 92 | 101.92 |
| Amoxicillin-clavulanate (high dose) | 2,000 mg every 12 hours§ | 91 | 112.09 |
| Ceftriaxone (Rocephin) | 1 g every 24 hours | 91 | 255.80∥ |
| Combination therapy¶ | — | — | — |
| If beta-lactam allergic: | | | |
| Gatifloxacin, levofloxacin, moxifloxacin | As above | As above | As above |
| Clindamycin (Cleocin) plus rifampin (Rifadin)** | 150 to 450 mg every 6 hours, 300 mg every 12 hours | — | 76.49 to 183.19 (154.21 to 370.38) |