| Agent | Pathway | Type of report | Effect of St. John’s wort on drug levels in the blood |
|---|---|---|---|
| Amitriptyline (Elavil) | CYP P450 3A4 | One-arm trial29 | Decrease |
| Carbamazepine (Tegretol) | CYP 3A4 | One-arm trial30 | None |
| Cyclosporine (Sandimmune) | CYP 3A4 | One-arm trial31 | Decrease |
| Digoxin | CYP 3A4 | Clinical trial32 | Decrease |
| Indinavir (Crixivan) | CYP 3A4 | One-arm trial33 | Decrease |
| Irinotecan (Camptosar) | CYP 3A4 | Crossover trial34 | Decrease |
| Midazolam (Versed) | CYP3A | Clinical trial35 | Decrease |
| Nevirapine (Viramune) | CYP 3A4 | One-arm trial36 | Decrease |
| Oral contraceptives | CYP 3A4 | Clinical trial35 | Decrease |
| Sertraline (Zoloft) | CYP P450 3A4 | One-arm trial37 | Decrease |
| Simvastatin (Zocor) | CYP 3A4 | Clinical trial38 | Decrease |
| Tacrolimus (Prograf) | CYP 3A4 | One-arm trial31 | Decrease |
| Theophylline | CYP 1A2 | Case report39 | Decrease |
| Warfarin (Coumadin) | CYP 2C9 | Case report40 | Decrease |