Montelukast (Singulair) | Adults: 10 mg before bed | | $104.40 (4 mg, 5 mg, or 10 mg) |
Children six to 14 years: 5 mg before bed |
Children two to five years: 4 mg before bed |
Zafirlukast (Accolate) | Patients older than 11 years: 20 mg twice daily |
Renal adjustments: none Hepatic adjustments: not defined Monitor hepatic enzymes every two to three months Administration with meals decreases bioavailability; take at least one hour before meals or two hours after Inhibits metabolism of warfarin (Coumadin), increasing prothrombin time
| $88.10 (10 mg or 20 mg) |
Children seven to 11 years: 10 mg twice daily |
Zileuton (Zyflo) | Patients older than 12 years: 600 mg four times daily | Can inhibit metabolism of warfarin, theophylline, and propranolol (Inderal) Monitor hepatic enzymes every two to three months
| $273.75 (600 mg) |