DrugAge and recommended oral doseTherapeutic issuesApproximate monthly cost*
Montelukast (Singulair)Adults: 10 mg before bed
  • Renal adjustments: none

  • Hepatic adjustments: in mild to moderate disease

$104.40 (4 mg, 5 mg, or 10 mg)
Children six to 14 years: 5 mg before bed
Children two to five years: 4 mg before bed
Zafirlukast (Accolate)Patients older than 11 years: 20 mg twice daily



  • Renal adjustments: none

  • Hepatic adjustments: not defined

  • Monitor hepatic enzymes every two to three months

  • Administration with meals decreases bioavailability; take at least one hour before meals or two hours after

  • Inhibits metabolism of warfarin (Coumadin), increasing prothrombin time

$88.10 (10 mg or 20 mg)
Children seven to 11 years: 10 mg twice daily
Zileuton (Zyflo)Patients older than 12 years: 600 mg four times daily
  • Can inhibit metabolism of warfarin, theophylline, and propranolol (Inderal)

  • Monitor hepatic enzymes every two to three months

$273.75 (600 mg)