DrugInitial doseMaximal single dose
Loop diuretics
Bumetanide (Bumex)1.0 mg4 to 8 mg
Furosemide (Lasix)40 mg160 to 200 mg
Torsemide (Demadex)10 mg100 to 200 mg
Thiazide diuretics
Chlorothiazide (Diuril)500 mg1,000 mg
Sequential nephron blockade
Chlorothiazide500 to 1,000 mg one or two times plus loop diuretics once—multiple doses per day
Metolazone (Zaroxolyn)2.5 to 5 mg orally one or two times per day with loop diuretic
Intravenous infusions
Bumetanide1 mg load then 0.5 to 2 mg per hour
Furosemide40 mg load then 10 to 40 mg per hour
Torsemide20 mg load then 5 to 20 mg per hour