| Dopamine D2 antagonists (high-potency) | Perphenazine (Trilafon‡) | 1957 | 16 mg twice daily | $83 to $93 |
| Trifluoperazine (Stelazine‡) | 1959 | 6 mg twice daily | $150 to $234 |
| Fluphenazine (Prolixin‡) | 1960 | 2.5 mg twice daily | $45 to $54 |
| Haloperidol (Haldol) | 1967 | 5 mg three times daily | $9 to $88 |
| Thiothixene (Navane) | 1967 | 10 mg three times daily | $148 (brand); $37 to $60 (generic) |
| Fluphenazine decanoate (Prolixin Decanoate‡) | 1972 | 25 mg IM every three weeks | $5 to $15 |
| Haloperidol decanoate (Haldol Decanoate) | 1986 | 100 mg IM every four weeks | $86 (brand); $19 to $53 (generic) |
| Dopamine D2 antagonists (mid-potency) | Molindone (Moban) | 1974 | 25 mg three times daily | $271 |
| Loxapine (Loxitane) | 1975 | 50 mg twice daily | $242 (brand); $154 (generic) |
| Dopamine D2 antagonists (low-potency) | Chlorpromazine (Thorazine‡) | 1957 | 100 mg three times daily | $6 to $103 |
| Thioridazine (Mellaril‡) | 1962 | 100 mg three times daily | $15 to $62 |
| Atypical (mixed neuroreceptor antagonists [low-affinity D2 antagonists, high-affinity 5HT2A antagonists]) | Clozapine (Clozaril) | 1989 | 125 mg twice daily | $407 (brand); $266 to $284 (generic) |
| Risperidone (Risperdal) | 1993 | 4 mg once daily | $317 |
| Olanzapine (Zyprexa) | 1996 | 10 mg once daily | $353 |
| Quetiapine (Seroquel) | 1997 | 200 mg twice daily | $397 |
| Ziprasidone (Geodon) | 2001 | 40 mg twice daily | $315 |
| Aripiprazole (Abilify) | 2002 | 20 mg once daily | $490 |