MedicationTypical dosage range per dayCost*Lower dose in renal/liver diseases
Selected SSRIs
Citalopram (Celexa)20 to 60 mg$9 to 78 (20 mg, #30)No/yes
Escitalopram (Lexapro)10 to 20 mg81 (10 mg, #30)No/yes
Fluoxetine (Prozac)20 to 80 mg9 to 80 (20 mg, #30)No/yes
Paroxetine (Paxil, Paxil CR)20 to 50 mg (25 to 62.5 mg [CR])50 to 82 (20 mg, #30), 104 (25 mg [CR], #30)Yes/yes
Sertraline (Zoloft)50 to 200 mg13 to 86 (50 mg, #30)No/yes
SNRIs
Duloxetine (Cymbalta)30 to 90 mg121 (30 mg, #30)Yes/avoid
Venlafaxine, extended release (Effexor XR)37.5 to 225 mg110 (75 mg, #30)Yes/yes
Other second-generation antidepressants
Bupropion SR (Wellbutrin SR)100 to 200 mg, twice daily94 to 120 (150 mg, #60)Yes/yes
Bupropion XL (Wellbutrin XL)150 to 450 mg164 (300 mg, #30)Yes/yes
Mirtazapine (Remeron)15 to 45 mg78 to 81 (15 mg, #30)Yes/yes
Nefazodone (Serzone, brand no longer available in the United States)100 to 300 mg, twice daily92 (100 mg, #60)No/
Trazodone (Desyrel, brand no longer available in the United States)150 to 600 mg44 to 85 (150 mg, #30)No/yes
Selected TCAs
Amitriptyline (Elavil, brand no longer available in the United States)25 to 300 mg1 to 19 (50 mg, #30)No/yes
Imipramine (Tofranil)25 to 200 mg2 to 37 (50 mg§, #30)No/yes
Nortriptyline (Pamelor)25 to 150 mg24 (25 mg, #30)Yes/yes