| Demonstrated to decrease mortality and improve symptoms† |
| Angiotensin-converting enzyme inhibitors |
| Captopril (Capoten) | 6.25 mg three times daily (½ tablet‡) | 12.5 to 50 mg three times daily | $28 to 69 | $162 |
| Lisinopril (Prinivil, Zestril) | 5 mg daily | 10 to 20 mg daily | 9 to 30 | 32, 40 |
| Enalapril (Vasotec) | 2.5 mg twice daily | 10 mg twice daily | 64 to 75 | 94 |
| Trandolapril (Mavik) | 1 mg daily | 4 mg daily | 36 | 40 |
| Ramipril (Altace) | 1.25 mg twice daily | 5 mg twice daily | NA | 104 |
| Beta blockers |
| Bisoprolol (Zebeta) | 1.25 mg daily (¼ tablet‡) | 10 mg daily | 37 to 68 | 82 |
| Metoprolol succinate (Toprol-XL) | 12.5 mg daily (½ tablet) | 200 mg daily | 65 | 69 |
| Carvedilol (Coreg) | 3.125 mg twice daily | 25 mg twice daily | 117 to 127 | 126 |
| Aldosterone antagonists |
| Spironolactone (Aldactone) | 12.5 mg daily | 25 mg daily | 14 to 29 | 25 |
| Eplerenone (Inspra) | 25 mg daily | 50 mg daily | NA | 119 |
| Vasodilators |
| Isosorbide dinitrate/hydralazine (Bidil) | 20/37.5 mg three times daily | 40/75 mg three times daily | NA | 405 |
| Isosorbide dinitrate | 20 mg three times daily | 40 mg three times daily | 38 to 45 | NA |
| Hydralazine | 37.5 mg three times daily | 75 mg three times daily | 108 to 137 | NA |
| Angiotensin receptor blockers |
| Candesartan (Atacand) | 4 mg daily | 32 mg daily | NA | 75 |
| Valsartan (Diovan) | 40 mg twice daily | 160 mg twice daily | NA | 133 |
| Symptomatic therapy§ |
| Loop diuretics‖ |
| Furosemide (Lasix) | 40 mg daily | 40 to 400 mg one to three times daily | 5 | 11 |
| Bumetanide (Bumex) | 1 mg daily | 1 to 10 mg one to three times daily | 13 to 16 | 27 |
| Ethacrynic acid (Edecrin) | 25 mg daily | 25 to 200 mg once or twice daily | NA | 27 |
| Torsemide (Demadex) | 20 mg daily | 20 to 100 mg once or twice daily | 25 to 45 | 38 |
| Thiazide diuretics‖ |
| Hydrochlorothiazide | 25 mg daily | 25 to 100 mg daily | 1 to 3 | NA |
| Metolazone (Zaroxolyn) | 2.5 mg daily | 2.5 to 10 mg daily | 39 to 79 | 47 |
| Inotrope |
| Digoxin¶ | 0.125 mg daily | 0.125 to 0.375 mg daily | 6 | 8 |