| First-generation antipsychotics | Weight gain is generally less than with second-generation antipsychotics, but the effects are widely variable |
| Second-generation antipsychotics* |
| Aripiprazole (Abilify) | Similar to placebo16 |
| Clozapine (Clozaril) | Average weight gain at 10 weeks: 9 lb, 13 oz (4.45 kg)17,18 |
| Olanzapine (Zyprexa) | Average weight gain at 10 weeks: 9 lb, 2 oz (4.15 kg)17,18 |
| Quetiapine (Seroquel) | Weight gain ranges from minimal to a mean gain of 5 lb, 8 oz (2.49 kg) at six weeks17 |
| Risperidone (Risperdal) | Average weight gain at 10 weeks: 4 lb, 10 oz (2.10 kg)17,18 |
| Ziprasidone (Geodon) | Average weight gain at 10 weeks: 1 oz (0.04 kg)18 |