AgentUsual initial dosageUsual dosage range*Cost of brand (generic)
Antidepressants
Duloxetine (Cymbalta)30 mg daily30 to 120 mg daily$127
Escitalopram (Lexapro)10 mg daily10 to 20 mg daily91
Imipramine (Tofranil)‡25 to 50 mg daily100 to 300 mg daily282 (28)
Paroxetine (Paxil)20 mg daily20 to 50 mg daily110 (49 to 82)
Sertraline (Zoloft)‡25 to 50 mg daily50 to 200 mg daily107 (81 to 85)
Venlafaxine (Effexor)‡37.5 mg two times daily75 to 375 mg, divided, two to three times daily81 (66 to 78)
Benzodiazepines
Alprazolam (Xanax)0.25 to 0.5 mg three times daily0.5 to 6 mg daily49 (9 to 30)
Chlordiazepoxide (Librium)5 to 10 mg two to three times daily10 to 25 mg two to four times daily129 (20 to 30)
Clonazepam (Klonopin)‡0.25 mg two times daily0.5 to 4 mg, divided, two times daily37 (7 to 22)
Clorazepate (Tranxene)7.5 to 15 mg two times daily15 to 60 mg, divided, two to three times daily178 (62 to 96)
Diazepam (Valium)2 to 5 mg two to four times daily2 to 10 mg, divided, four times daily87 (25 to 40)
Lorazepam (Ativan)0.5 to 1 mg three times daily0.5 to 2 mg three times daily126 (49 to 56)
Oxazepam (formerly Serax)10 mg three times daily10 to 30 mg three to four times daily92 (40 to 77)
Other
Buspirone (Buspar)7.5 mg two times daily30 to 60 mg, divided, two to three times daily172 (20 to 80)
Hydroxyzine (Vistaril)50 mg four times daily50 to 400 mg daily52 (3 to 20)
Pregabalin (Lyrica)‡75 mg two times daily200 to 600 mg daily135