| Prevention of serotonin syndrome requires clinical awareness of the toxic potential of serotonergic agents. | C | 1 | Education and use of drug interaction software may be helpful |
| Established criteria should be used to identify and diagnose serotonin syndrome. | C | 1, 14 | Hunter Serotonin Toxicity Criteria are more sensitive and specific than Sternbach's criteria in diagnosing serotonin syndrome |
| First-line management of serotonin syndrome involves withdrawal of the offending drugs and provision of supportive care. | C | 19 | — |
| Cyproheptadine may be used to treat moderate to severe cases of serotonin syndrome. | C | 19, 20 | Based on case reports |