| Chemotherapy24 | Anthracyclines |
| Doxorubicin (Adriamycin) | IV every 14 to 21 days for four to six cycles; used in combination with a taxane (docetaxel [Taxotere] or paclitaxel [Taxol]), cyclophosphamide, and/or fluorouracil |
| Epirubicin (Ellence) | IV day 1 or days 1 and 8, every 21 to 28 days for three to eight cycles; used in combination with cyclophosphamide or fluorouracil |
| Taxanes |
| Docetaxel | IV every 21 days for three to four cycles; used in combination with doxorubicin, epirubicin, cyclophosphamide, and/or fluorouracil |
| Paclitaxel | IV every seven to 21 days for four to 12 cycles; used in combination with doxorubicin and cyclophosphamide |
| Endocrine | Aromatase inhibitors |
| Anastrozole (Arimidex) | Oral tablet daily for five years; used alone or in sequence with tamoxifen36,37 |
| Exemestane (Aromasin) | Oral tablet daily for at least two to five years; used alone or in sequence with tamoxifen38,39 |
| Letrozole (Femara) | Oral tablet daily for two to five years; used alone or in sequence with tamoxifen40,41 |
| Gonadotropin-releasing hormone agonist |
| Goserelin (Zoladex) | Subcutaneously every one to three months for two years42,43 |
| Selective estrogen receptor modulators |
| Tamoxifen | Oral tablet daily for two to five years; used alone or in sequence with an aromatase inhibitor36 |
| Tissue-targeted | Monoclonal antibody |
| Trastuzumab (Herceptin) | IV with first dose of chemotherapy regimen and then every one or three weeks to complete one year44–46 |