| Weight loss strategies using dietary modification, physical activity, or behavioral interventions can produce and maintain weight loss for longer than one year. | B | 4, 25 | RCT and retrospective reviews |
| Sibutramine (Meridia) and orlistat (Xenical) were only modestly effective in reducing weight and maintaining weight loss in trials of one year or longer. | A | 32 | Cochrane review of RCTs |
| Successful long-term weight loss maintenance can be achieved with gastric bypass surgery in patients who are morbidly obese. | A | 33, 36 | Cochrane review of RCTs and retrospective reviews |
