Basal cell carcinoma | Locally invasive rodent, or Jacob, ulcer with rolled edges and central ulceration; pigmented or pearly gray with granular appearance; tends to affect the face |
Lichen sclerosus | Pruritic, white, atrophic papules and plaques; discrete or confluent with central depression |
Melanoma | Mass or nodule with bleeding, discharge, dysuria, and pain; usually pigmented; rarely affects genitalia, but more common on clitoris or labia minora |
Squamous cell carcinoma | Unifocal plaque, ulcer, or mass; pruritic area becomes red, nonhealing wound |
Syphilis | Chancre appears as painless papule or area of infiltration that is a dull red color and hard, then center erodes and becomes ulcerated; chancre heals on its own, followed by a generalized rash |