Substance	Street name	Signs and symptoms of intoxication	Treatment
Caffeine (e.g., energy drinks, caffeine pills)	NA	Restlessness, nervousness, insomnia, tachyarrhythmias, psychomotor agitation, withdrawal, headache	Supportive care
Chlorpheniramine	DXM, robo, CCC, skittles, poor man's PCP, velvet, rojo, candy	Respiratory depression, hyperthermia, rhabdomyolysis, seizures, flushing, tachycardia, agitated delirium, urinary retention, cardiac arrhythmias	Supportive care; benzodiazepines for seizures
Chlorpheniramine plus dextromethorphan	DXM, robo, CCC, skittles, poor man's PCP, velvet, rojo, candy	Tachycardia, somnolence, agitation, hallucinations, hypertension, disorientation, slurred speech, syncope, seizure	Supportive care; benzodiazepines for seizures
Dextromethorphan	DXM, robo, CCC, skittles, poor man's PCP, velvet, rojo, candy	Hyperexcitability, lethargy, ataxia, slurred speech, sweating, temperature instability, hypertension, nystagmus, seizures, death	Supportive care; testing for concomitant ingestion of other drugs
Dimenhydrinate	Dime tabs, dime, substance D	Euphoria, hallucinations, flushing, tachycardia, agitated delirium, convulsions, urinary retention, cardiac arrhythmias, somnolence, coma	Clozapine (Clozaril) to reduce cravings
Diphenhydramine	NA	Flushing, tachycardia, agitated delirium, convulsions, urinary retention, cardiac arrhythmias, somnolence, coma	Supportive care
Nicotine (e.g., cigarettes, smokeless tobacco, nicotine replacement therapies)	Cigs, chew, dip, snuff, shisha, hubble-bubble	Mild euphoria, agitation	Smoking cessation; supportive care
Pseudoephedrine	NA; used to make methamphetamine	Priapism, hypertension, agitation, excitability, tachyarrhythmias	Supportive care