| Occasional | Carbidopa/levodopa (Sinemet), 10 to 25 mg/100 mg at bedtime, as needed | Opiates |
| Frequent | Dopaminergic agonist Pramipexole (Mirapex), 0.125 mg, or ropinirole (Requip), 0.25 mg, at bedtime; increase dose every third night to a maximum of four tablets or until symptoms are controlled
| Opiates |
| Nightly | Dopaminergic agonist Pramipexole, 0.125 mg, or ropinirole, 0.25 mg, at bedtime; increase dose every third night to a maximum of four tablets or until symptoms are controlled Rotigotine transdermal patch (Neupro), 1 mg per 24 hours; increase dosage once weekly to a maximum of 3 mg per 24 hours (for moderate to severe symptoms)
| Gabapentin (Neurontin) and pregabalin (Lyrica) Gabapentin, 300 mg at bedtime; increase dose every three or four nights to a maximum of 1,800 mg Pregabalin, 25 mg at bedtime, increase dose every four nights to a maximum of 100 mg
Opiates |
| Painful | Gabapentin and pregabalin Gabapentin, 300 mg at bedtime; increase dose every three or four nights to a maximum of 1,800 mg Pregabalin, 25 mg at bedtime; increase dose every four nights to a maximum of 100 mg
Opiates | Dopaminergic agonists Pramipexole, 0.125 mg, or ropinirole, 0.25 mg, at bedtime; increase dose every third night to a maximum of four tablets or until symptoms are controlled Rotigotine transdermal patch, 1 mg per 24 hours; increase dosage once weekly to a maximum of 3 mg per 24 hours
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