| Ageratina pichinchensis (snakeroot) extract33 | Apply every third day for the first month, twice per week for the second month, then once per week for the third month | 71 | 59 | Study of 110 patients; therapeutic effectiveness was similar to that in the control group, which used ciclopirox |
| Cyanoacrylate, undecylenic acid, and hydroquinone (Renewed Nail)34 | Soak and debride affected nails, then apply solution every two weeks for three to four visits; patients may also apply at home | NA | 50 to 65 (mild to moderate cases) | Study of 154 patients with cure rates reported after three months |
| 35 (severe cases) |
| Dual-wavelength near-infrared laser (Noveon)35 | Treatment on days 1, 14, 42, and 120 | Mild cases: 65 (3 mm of nail clearance) 26 (4 mm of nail clearance) | 30 | Toenails were evaluated on day 180 |
| Moderate to severe cases: 63 (3 mm of nail clearance) |
| Melaleuca alternifolia (tea tree) oil36 | Apply twice per day | NA | NA | Cochrane review found no evidence of benefit31 |
| Mentholated ointment (Vicks Vaporub)37 | Apply small amount with cotton swab daily | 28 | 28 | Pilot study of 18 patients; 56% had partial clearance, and 17% had no clearance |
| Neodymium: yttrium-aluminum-garnet laser (Patholase Pinpointe)38 | One to three sessions four to six weeks apart | NA | 61 (complete cure) | Study of 37 toenails with onychomycosis |
| 19 (significant improvement) |
| 11 (moderate improvement) |
