Medication	Drug class	Pregnancy risk category*	Crosses the placenta?	Use in pregnancy
Acetaminophen	Nonnarcotic analgesic/antipyretic	B	Yes	Drug of choice
Aspirin	Salicylate analgesic/antipyretic	C in the first and second trimesters, D in the third trimester	Yes	Should be avoided in pregnancy unless needed for specific indications
Naproxen	NSAID analgesic	C in the first and second trimesters, D in the third trimester [ corrected]	Yes	Should be avoided in the third trimester
Ibuprofen	NSAID analgesic	C in the first and second trimesters, D in the third trimester	Yes	Should be avoided in the third trimester