Liraglutide (Saxenda)

0.6, 1.2, 1.8, 2.4, or 3 mg per day subcutaneously

Glucagon-like peptide-1 receptor agonist

1.2 mg: 4.6 lb (2.1 kg)

1.8 mg: 6.2 lb (2.8 kg)

2.4 mg: 7.7 lb (3.5 kg)

3 mg: 9.7 to 13 lb (4.4 to 5.9 kg)

20 to 56 weeks

Abdominal pain, constipation, decreased appetite, diarrhea, dizziness, fatigue, headache, hypoglycemia, increased lipase levels, nausea, vomiting

Personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2

2014

Lorcaserin (Belviq)

10 mg two times per day

5-HT2C receptor agonist

7 lb (3.2 kg)

One to two years

Back pain, constipation, cough, dizziness, dry mouth, fatigue, headache, hypoglycemia, nausea

—

2012

Naltrexone/bupropion (Contrave)

Two 8/90-mg tablets two times per day

Opioid antagonist/aminoketone antidepressant

16 mg: 7.7 lb

32 mg: 10.4 to 10.8 lb (4.7 to 4.9 kg)

56 weeks

Constipation, diarrhea, dizziness, dry mouth, headache, insomnia, nausea, vomiting

Abrupt discontinuation of alcohol, benzodiazepines, barbiturates, or antiepileptics; anorexia nervosa; bulimia; long-term opioid use; seizure disorder; uncontrolled hypertension; use of a monoamine oxidase inhibitor within 14 days

2014

Orlistat (Xenical)

60 or 120 mg three times per day

Lipase inhibitor

60 mg: 5.5 lb (2.5 kg)

120 mg: 7.5 lb (3.4 kg)

One to four years

Fecal incontinence, fecal urgency, flatus, increased defecation, oily stool

Cholestasis, chronic malabsorption syndrome

1999

Phentermine/topiramate (Qsymia)

7.5/46 mg per day

15/92 mg per day

Sympathomimetic/antiepileptic

7.5/46 mg: 14.8 lb (6.7 kg)

15/92 mg: 19.6 lb (8.9 kg)

56 to 108 weeks

Constipation, dizziness, dry mouth, dysgeusia, insomnia, paresthesia

Glaucoma, hyperthyroidism, use of a monoamine oxidase inhibitor within 14 days

2012