Medication	Dosage	Adverse effects	Comments	U.S. Food and Drug Administration pregnancy risk
Combined oral contraceptives	One tablet daily	Headache, nausea	First-line agents; may be used in combination with antiandrogens	Accidental use in pregnancy is low risk; may decrease lactation
Eflornithine (Vaniqa)	Apply topically twice daily	Acne, local irritation	Expensive	Safety risks unknown
Finasteride (Propecia)	2.5 mg daily	Decreased libido	Additive benefit when used with spironolactone	High risk of feminization of male fetus
Glucocorticoids	Prednisone: 5 mg twice daily	Adrenal suppression, bone density loss, weight gain	Use in patients with congenital adrenal hyperplasia	Increased risk of growth retardation and cleft palate, especially if used in first trimester
Leuprolide (Lupron)	3.75 mg intramuscularly monthly	Bone density loss, hot flashes, vaginal dryness	Consider using in conjunction with combined oral contraceptives	High risk of fetal harm
Spironolactone	100 to 200 mg daily	Breast tenderness, hyperkalemia, irregular menses	Risk of breast adenomas in murine testing	Increased risk of spontaneous abortion and feminization of male fetus