Medication*	Adverse effects	Pregnancy/children†	Cost‡
Azelaic acid (Azelex, Finacea)§	Burning, dryness, stinging, erythema, pruritus, hypersensitivity reaction, asthma exacerbation, hypopigmentation in individuals with dark skin	May use during pregnancy; no human data available, although risk of fetal harm is not expected based on minimal systemic absorption Safety and effectiveness not established in children younger than 12 years	20% cream: — ($680) for a 50-g tube 15% gel: $120 ($345) for a 50-g tube
Benzoyl peroxide	Burning, dryness, stinging, erythema, peeling, hypersensitivity, bleaching of hair or clothing	May use during pregnancy; inadequate human data available, although risk of fetal harm is not expected based on minimal systemic absorption Safety and effectiveness not established in children younger than 12 years	Variable cost based on over-the-counter vs. prescription, brand vs. generic, formulation (many available), and size
Dapsone (Aczone)	Burning, dryness, erythema, pruritus, orange staining of skin	May use during pregnancy; no human data available, although risk of fetal harm is not expected based on minimal systemic absorption Safety and effectiveness not established in children younger than 12 years	5% gel: $250 ($665) for a 60-g tube 7.5% gel: — ($665) for a 60-g tube