Medication*	Adverse effects	Pregnancy/children†	Cost‡
Clindamycin 1% (Cleocin, Evoclin)	Pruritus, erythema, dryness, peeling, Clostridium difficile colitis, folliculitis, photosensitivity	May use during pregnancy; no human data available, although risk of fetal harm is not expected based on minimal systemic absorption Safety and effectiveness not established in children younger than 12 years	Gel: $70 ($285) for a 60-g tube Lotion: $50 ($220) for 60-mL bottle Solution: $30 ($150) for a 60-mL bottle Foam: $190 ($500) for a 50-g can
Clindamycin 1%/benzoyl peroxide 5% (Benzaclin)	Pruritus, erythema, dryness, peeling, C. difficile colitis, anaphylaxis	May use during pregnancy; no human data available, although risk of fetal harm is not expected based on expected limited systemic absorption Safety and effectiveness not established in children younger than 12 years	Gel: $70 ($190) for a 25-g jar
Erythromycin 2% (Erygel, Ery)	Dryness, irritation, C. difficile colitis	May use during pregnancy; no human data available, although risk of fetal harm not expected based on minimal systemic absorption Safety and effectiveness not established in children younger than 12 years	Gel: $70 ($12§) for a 60-g tube Solution: $25 (—) for a 60-mL bottle Pads: $40 ($40) for 60 pledgets
Erythromycin 3%/benzoyl peroxide 5% (Benzamycin)	Pruritus, erythema, dryness, peeling, burning, urticaria, C. difficile colitis	May use during pregnancy; no human data available, although risk of fetal harm is not expected based on minimal systemic absorption Safety and effectiveness not established in children younger than 12 years	Gel: $130 ($85) for a 46.6-g jar