Medication*	Adverse effects	Pregnancy/children†	Cost‡
Adapalene (Differin)	Burning, peeling, stinging, pruritus, erythema, dryness, photosensitivity	May use during pregnancy; risk of fetal harm not expected based on limited human data and insignificant systemic absorption Approved for use in children 12 years and older	Cream: $100 ($380) for a 45-g tube 0.1% gel: $70 ($600) for a 45-g tube 0.3% gel: $100 ($360) for a 45-g tube Lotion: $300 ($350) for a 59-mL bottle
Adapalene/benzoyl peroxide (Epiduo)	Burning, peeling, stinging, pruritus, erythema, dryness, photosensitivity	May use during pregnancy; risk of fetal harm not expected based on limited human data and insignificant systemic absorption Approved for use in children nine years and older	0.1%/2.5% gel: $80 ($360) for a 45-g pump 0.3%/2.5% gel: — ($480) for a 45-g pump
Clindamycin phosphate/tretinoin (Veltin, Ziana)	Burning, peeling, stinging, pruritus, erythema, dryness, photosensitivity, colitis	Consider avoiding use during pregnancy, especially in the first trimester Approved for use in children 12 years and older	1.2%/0.025% gel: $300 ($740) for a 60-g tube
Tazarotene (Tazorac)	Burning, peeling, stinging, pruritus, erythema, dryness, photosensitivity	Use alternative during pregnancy Approved for use in children 12 years and older	0.05% cream: — ($830) for a 60-g tube 0.1% cream: $250 ($875) for a 60-g tube 0.05% gel: — ($415) for a 30-g tube 0.01% gel: — ($440) for a 30-g tube
Tretinoin (Retin-A, Atralin)	Burning, peeling, stinging, pruritus, erythema, dryness, photosensitivity	Consider avoiding use during pregnancy, especially in the first trimester Approved for use in children 10 years and older	Cream (for a 45-g tube):  0.025%: $85 ($100)  0.05%: $100 ($100)  0.1%: $150 ($100)
			Gel (for a 45-g tube):  0.01%: $90 ($100)  0.025%: $60 ($100)  0.05%: $200 ($600)
			Microsphere (for a 45-g tube):  0.04%: $200 ($800)  0.1%: $200 ($800)