Medication	Dosage	Adverse effects	Pregnancy/children*	Cost†
Doxycycline (Vibramycin, Acticlate)	Children: 2 mg per kg per dose every 12 hours on day 1, then 2 mg per kg once per day thereafter (maximum dose is 100 mg) Adults: 50 to 100 mg once or twice per day	Nausea, diarrhea, dyspepsia, esophagitis, headache, vaginal candidiasis, photosensitivity, tooth/bone discoloration, pseudotumor cerebri, hepatotoxicity, Clostridium difficile colitis	Avoid use during pregnancy Safety and effectiveness not established in children younger than eight years	$15 ($380) for 30 100-mg capsules $300 ($1,100) for 30 150-mg tablets
Erythromycin‡	Children and adults: 250 to 500 mg two to four times per day	Nausea, vomiting, drug interactions, arrhythmias	May use during pregnancy; possible risk of fetal harm based on conflicting human data Safe for use in children	$480 (—) for 60 250-mg tablets
Minocycline (Minocin)	Children: 1 mg per kg once per day Adults: 50 mg one to three times per day	Nausea, vomiting, diarrhea, vestibular dysfunction, photosensitivity, hyperpigmentation, pseudotumor cerebri, lupus-like reaction, drug reaction with eosinophilia and systemic symptoms, hepatotoxicity, Stevens-Johnson syndrome	Avoid use during pregnancy Not indicated in children younger than eight years	$15 ($850) for 30 50-mg capsules $40 (—) for 30 50-mg tablets
Sarecycline (Seysara)	Children and adults  33 to 54 kg (73 to 119 lb): 60 mg per day  55 to 84 kg (121 to 185 lb): 100 mg per day  85 to 136 kg (187 to 300 lb): 150 mg per day Treat for 12 weeks then reassess	Nausea, lightheadedness, dizziness, vertigo, headache, vaginal candidiasis, photosensitivity, tooth/bone discoloration, pseudotumor cerebri, hepatotoxicity, C. difficile colitis	Avoid use during pregnancy or while breastfeeding Avoid use in children younger than nine years	— ($900) for 30 tablets of any strength
Tetracycline	Children: 25 to 50 mg per kg per day in two to four divided doses Adults: 250 to 500 mg once or twice per day	Nausea, vomiting, diarrhea, abdominal pain, photosensitivity, tooth and nail discoloration, pseudotumor cerebri, hepatotoxicity, urticaria	Avoid use during pregnancy Not indicated in children younger than eight years	$70 (—) for 30 250-mg capsules
Trimethoprim/sulfamethoxazole‡	Children and adults: 160/800 mg twice per day	Stevens-Johnson syndrome, toxic epidermal necrolysis, hepatotoxicity, bone marrow suppression, drug eruptions	Consider alternative during pregnancy; possible risk of spontaneous abortion based on limited human data; possible risk of congenital neural tube and cardiovascular defects based on conflicting human data and trimethoprim's mechanism of action Safety and effectiveness not established in children younger than two months	$15 (—) for 60 160/800-mg tablets