Presence of any three of these five criteria is diagnostic:

Blood pressure

≥ 130 mm Hg systolic or ≥ 85 mm Hg diastolic, or antihypertensive pharmacotherapy needed in a patient with a history of hypertension

Fasting glucose level

≥ 100 mg per dL (5.55 mmol per L) or pharmacotherapy needed for elevated glucose level

HDL cholesterol level

< 50 mg per dL (1.29 mmol per L) in women or < 40 mg per dL (1.04 mmol per L) in men, or pharmacotherapy needed for reduced HDL cholesterol level

Triglyceride level

≥ 150 mg per dL (1.69 mmol per L) or pharmacotherapy needed for elevated triglyceride level

Waist circumference

≥ 35 in (89 cm) in women or ≥ 40 in (102 cm) in men