Monitoring ALT, AST, and CBC after initiation of terbinafine or griseofulvin therapy has very low yield20 | In healthy adults treated for dermatophyte infection with terbinafine or griseofulvin, do not obtain baseline or follow-up ALT level, AST level, or CBC. |
Behavior therapies are better than drug therapy for urinary incontinence in women21 | In women with urge, stress, or mixed urinary incontinence, recommend a trial of a behavior therapy before prescribing an anticholinergic drug. Avoid hormone treatment and injections designed to provide periurethral bulking. |
Tramadol is no less likely than other opioids to reduce the risk of long-term use22 | In the postoperative period, do not preferentially prescribe tramadol over other short-acting opioids to prevent opioid dependence. |
Probiotics are ineffective for the treatment of acute gastroenteritis in young children23 | In preschool-aged children with acute diarrhea, do not recommend the probiotic lactobacillus GG. |
“Augmentation” of antidepressant treatment offers little benefit24 | In treatment-resistant depression, consider cognitive behavior therapy; do not prescribe lithium before a trial of aripiprazole (Abilify). |