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Targeted Cancer Therapies

Targeted cancer therapies involve chemotherapeutic agents that attack, directly or indirectly, a specific genetic biomarker found in a given cancer. Targeted oncology includes monoclonal antibodies, small molecule inhibitors, antibody-drug conjugates, and immunotherapy. For example, the monoclonal antibodies trastuzumab and pertuzumab target human epidermal growth factor receptor 2 (HER2) and are used when treating HER2-positive breast cancer. Although targeted oncology has improved survival by years for some incurable cancers such as metastatic breast and lung cancer, as few as 8% of patients with advanced cancer qualify for targeted oncology medications, and even fewer benefit. Other limitations include serious adverse events, illustrated by a 20% to 30% rate of heart attack, stroke, or peripheral vascular events among patients taking ponatinib, which is used in treating chronic myelogenous leukemia. Immune checkpoint inhibitor therapy–related adverse effects such as hypothyroidism are common, and more severe adverse events such as colitis and pneumonitis can be fatal and require immediate intervention. Drug interactions with widely prescribed medications such as antacids and warfarin are common. Additionally, financial toxicities are a problem for patients with cancer who are using costly targeted therapies. Future directions for targeted oncology include tumor-agnostic drugs, which target a given mutation and could be used in treating cancers from multiple organ types. An overview of indications, mechanism of action, and toxicities of targeted cancer therapies is offered here.

Targeted cancer therapy involves testing various types of cancer for genetic biomarkers that can predict the response to chemotherapeutic agents that attack the biomarkers directly or indirectly.1,2 In the past decade, the U.S. Food and Drug Administration (FDA) has approved approximately 40 new targeted therapies for 12 different cancers36 (Table 1). Despite this innovation, the percentage of patients with cancer who are eligible for such therapies is small. In 2018, an estimated 8.3% of 610,000 patients with advanced or metastatic cancer were eligible for targeted therapy.7 The number of patients who benefit from these drugs is even smaller and ranges widely, depending on the tumor and drug. Targeted oncology has mainly shown benefit in the metastatic (incurable) setting, with rare success for patients treated with surgery in the local or regional setting.

WHAT'S NEW ON THIS TOPIC

Targeted Cancer Therapies

In the past decade, the U.S. Food and Drug Administration has approved approximately 40 new targeted therapies for 12 different cancers.

Patients with metastatic epidermal growth factor receptor–mutated lung cancer who are treated with osimertinib (Tagrisso) live a median of 39 months, more than double the survival of similar patients who were treated with the first epidermal growth factor receptor inhibitor, erlotinib (Tarceva), between 2007 and 2011.

In 2020, the average patient out-of-pocket cost for a course of oral cancer therapy was $5,663. According to one large analysis, 20% of patients with cancer take less medication than prescribed, 19% only partially fill oral cancer therapy prescriptions, and 24% avoid filling a prescription at all.

SORT: KEY RECOMMENDATIONS FOR PRACTICE

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CYP3A = cytochrome P450, family 3A; RCT = randomized controlled trial.

A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, go to https://www.aafp.org/afpsort.

TABLE 1.

FDA-Approved Targeted Therapies for Cancer, 2010 to 2019

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DrugsTargetDrug typeFDA-approved indicationToxicities, adverse effects, precautionsUnique monitoring
Acute myelogenous leukemia
Enasidenib (Idhifa), ivosidenib (Tibsovo)IDH1/2Small molecule inhibitorsNewly diagnosed and relapsed/refractory IDH1/2+ acute myelogenous leukemiaEdema, hepatotoxicity, prolonged QTcAlkaline phosphatase, ALT, AST, CBC, chemistry, CK, ECG, total bilirubin
Gilteritinib (Xospata), midostaurin (Rydapt)FLT3Small molecule inhibitorsNewly diagnosed and relapsed/refractory FLT3+ acute myelogenous leukemiaHepatotoxicity, prolonged QTc, rash, vomitingAlkaline phosphatase, ALT, AST, CBC, chemistry, ECG, total bilirubin
Anaplastic thyroid cancer
Dabrafenib (Tafinlar) plus trametinib (Mekinist)BRAF and MEKSmall molecule inhibitorsLocally advanced or metastatic with V600E mutationColitis, cutaneous squamous cell cancers, fever, heart failure, hepatotoxicity, hyperglycemia, rash, thrombosisAlkaline phosphatase, ALT, AST, blood glucose, ECG, electrolytes, renal function, skin examination, total bilirubin
Bladder cancer
Erdafitinib (Balversa)FGFR2/3Small molecule inhibitorMetastatic or locally advanced FGFR2/3 alterationsCentral serous retinopathy, hand-foot syndrome, hyperphosphatemia, oncholysisEye examination, phosphate
Breast cancer
Ado-trastuzumab emtansine (Kadcyla)HER2Antibody-drug conjugateEarly stage HER2+ with residual disease after neoadjuvant treatment; metastatic HER2+Cardiotoxicity, hepatotoxicity, interstitial lung disease, neuropathyAlkaline phosphatase, ALT, AST, CBC, ECG, total bilirubin
Alpelisib (Piqray)PIK3CASmall molecule inhibitorPIK3CA-mutated metastaticDermatologic (Stevens-Johnson syndrome), hyperglycemia, severe diarrheaA1C, blood glucose
Atezolizumab (Tecentriq)PD-L1ImmunotherapyPD-L1–positive metastatic triple negative breast cancer, in combination with chemotherapyColitis, endocrinopathies, hepatitis, myocarditis, pneumonitis, rashAlkaline phosphatase, ALT, AST, blood glucose, renal function, total bilirubin, TSH
Fam-trastuzumab deruxtecan (Enhertu)HER2Antibody-drug conjugateMetastatic HER2+Cardiotoxicity, hematologic, interstitial lung disease (9%)CBC, echocardiography
Olaparib (Lynparza), talazoparib (Talzenna)Poly- (adenosine diphosphate-ribose) polymeraseSmall molecule inhibitorsBreast cancer gene–mutated metastaticHematologic, increased mean corpuscular volume, pneumonitis, rare acute myelogenous leukemiaCBC, renal function
Pertuzumab (Perjeta)HER2Monoclonal antibodyMetastatic, neoadjuvant, and adjuvant HER2+Cardiotoxicity, diarrheaEchocardiography
Chronic lymphocytic leukemia
Ibrutinib (Imbruvica)BTKSmall molecule inhibitorChronic lymphocytic leukemia with 17p deletionAtrial fibrillation, diarrhea, edema, hemorrhageAlkaline phosphatase, ALT, AST, CBC, renal function, total bilirubin
Venetoclax (Venclexta)BCL2Small molecule inhibitorChronic lymphocytic leukemia with 17p deletionSevere pancytopenia, tumor lysis syndromeCBC, electrolytes, renal function; may require hospitalization for tumor lysis syndrome monitoring
Chronic myelogenous leukemia
Bosutinib (Bosulif), dasatinib (Sprycel), nilotinib (Tasigna), ponatinib (Iclusig)BCR-ABLSmall molecule inhibitorsInitial treatment: dasatinib, nilotinib, bosutinib; second-line treatment or T315I mutation: ponatinibArterial thrombotic events (ponatinib), diarrhea (bosutinib), edema, effusions (dasatinib), heart failure (all), hematologic, pancreatitis, prolonged QTc (nilotinib)Alkaline phosphatase, ALT, AST, blood pressure, CBC, chemistry, ECG, glucose, lipid profile, total bilirubin; provide low-dose aspirin with ponatinib
Colorectal cancer
Cetuximab (Erbitux)EGFRMonoclonal antibodyMetastatic without mutation in RASAcneiform rash, hypomagnesemiaElectrolytes
Gastroesophageal cancer
Trastuzumab (Herceptin)HER2Monoclonal antibodyMetastatic with HER2 overexpressionCardiotoxicityEchocardiography
Gastrointestinal stromal tumor
Imatinib (Gleevec)c-KITSmall molecule inhibitorAdjuvant following complete resection of c-KIT positive gastrointestinal stromal tumorEdema, heart failure, hematologicAlkaline phosphatase, ALT, AST, CBC, electrolytes, renal function, total bilirubin
Lung cancer (adenocarcinoma)
Afatinib (Gilotrif), dacomitinib (Vizimpro), erlotinib (Tarceva), gefitinib (Iressa), osimertinib (Tagrisso)EGFRSmall molecule inhibitorsMetastatic, EGFR exon 19 deletion or exon 21 (L858R) substitutionDiarrhea, hepatotoxicity, prolonged QTc, rash, trichiasisAlkaline phosphatase, ALT, AST, ECG, electrolytes, renal function, total bilirubin
Alectinib (Alecensa), brigatinib (Alunbrig), ceritinib (Zykadia), crizotinib (Xalkori), lorlatinib (Lorbrena)Anaplastic lymphoma kinaseSmall molecule inhibitorsMetastatic, anaplastic lymphoma kinase fusionBradycardia, hepatotoxicity, nausea, ocular toxicity, QT prolongation, vomitingAlkaline phosphatase, ALT, AST, CBC, renal function, total bilirubin
Crizotinib, entrectinib (Rozlytrek)ROS1Small molecule inhibitorsMetastatic, ROS1 positiveEntrectinib: cardiotoxicity, cognitive impairment, fractures, hepatotoxicity, ocular toxicityAlkaline phosphatase, ALT, AST, ECG, echocardiography, electrolytes, total bilirubin
DabrafenibBRAFSmall molecule inhibitorMetastatic, BRAF V600E mutationCutaneous squamous cell cancer, colitis, fever, heart failure, hepatotoxicity, hyperglycemia, rash, thrombosisAlkaline phosphatase, ALT, AST, blood glucose, echocardiography, skin examination, total bilirubin
Melanoma
Binimetinib (Mektovi), cobimetinib (Cotellic), dabrafenib, encorafenib (Braftovi), trametinib, vemurafenib (Zelboraf)BRAF + MEKSmall molecule inhibitorsMetastatic, V600E, V600K mutation (all) Adjuvant (dabrafenib + trametinib)BRAF inhibitors: alopecia, arthralgia, diarrhea, fatigue, nausea, rash
MEK inhibitors: diarrhea, rash, retinopathy
Alkaline phosphatase, ALT, AST, blood glucose, echocardiography, skin examination, total bilirubin
Mismatch repair deficient solid tumors
Ipilimumab (Yervoy), nivolumab (Opdivo), pembrolizumab (Keytruda)PD-1 or CTLA-4ImmunotherapiesMetastatic mismatch repair deficient solid tumorAdrenal insufficiency, colitis, myocarditis (rare but morbid), pneumonitis, rash, thyroiditisAlkaline phosphatase, ALT, AST, blood glucose, renal function, total bilirubin, TSH
Neurotrophin receptor kinase fusion solid tumors
Entrectinib, larotrectinib (Vitrakvi)Neurotrophin receptor kinaseSmall molecule inhibitorsMetastatic solid tumors with neurotrophin receptor kinase fusion proteinCardiotoxicity, cognitive impairment, fractures, hepatotoxicity, ocular toxicityAlkaline phosphatase, ALT, AST, ECG, echocardiography, total bilirubin
Ovarian
Niraparib (Zejula), olaparib, rucaparib (Rubraca)Poly- (adenosine diphosphate-ribose) polymeraseSmall molecule inhibitorsAdvanced or metastatic ovarian cancer with breast cancer gene mutationMyelodysplastic syndrome, pancytopeniaCBC

ALT = alanine transaminase; AST = aspartate transaminase; BCL2 = B-cell leukemia/lymphoma 2; BCR-ABL = a fusion gene when pieces of chromosomes 9 and 22 break off and trade places; BRAF = B-raf proto-oncogene; BTK = Bruton tyrosine kinase; c-KIT = gene encoding tyrosine-protein kinase KIT; CBC = complete blood count; CK = creatine kinase; CTLA-4 = cytotoxic T-lymphocyte–associated protein 4; ECG = electrocardiography; EGFR = epidermal growth factor receptor; FDA = U.S. Food and Drug Administration; FGFR2/3 = fibroblast growth factor receptor 2/3; FLT3 = fms-like tyrosine kinase 3; HER2 = human epidermal growth factor receptor 2; IDH1/2 = isocitrate dehydrogenase 1/2; MEK = MAP kinase-ERK kinase; PD-1 = programmed cell death protein 1; PD-L1 = programmed cell death ligand 1; PIK3CA = phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; ROS1 = receptor tyrosine kinase encoded by gene ROS1; TSH = thyroid-stimulating hormone.

Types of Targeted Therapy

Targeted therapies can be divided into four general categories: monoclonal antibodies, small molecule inhibitors, antibody-drug conjugates, and immunotherapy (Figure 1). In general, small molecule inhibitors are oral, whereas the remaining therapies are given intravenously.

FIGURE 1.

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Four mechanisms of targeted oncology. The monoclonal antibody pertuzumab (Perjeta) inhibits HER2 dimerization, inhibiting downstream pro-growth signals. The antibody-drug conjugate ado-trastuzumab emtansine (Kadcyla) links a HER2-targeted monoclonal antibody to a chemotherapy molecule, emtansine. Emtansine is internalized by the cell, leading to apoptosis. The small molecule inhibitor osimertinib (Tagrisso) binds to the intracellular portion of the EGFR, inhibiting progrowth signaling. Finally, the bottom half of the figure depicts a T-cell expressing MHC II engaged to a T-cell receptor on a tumor cell; it is unable to kill the tumor cell because PD-1 on the tumor cell is engaging the PD-L1 brake on the T-cell. Monoclonal antibodies against PD-L1 and PD-1 interrupt their binding, allowing the engaged T-cell to kill the tumor cell. Image created with Biorender.

MONOCLONAL ANTIBODIES

Monoclonal antibodies are identical immunoglobulins that bind a specific antigen. Targeted oncology monoclonal antibodies are most commonly used to target an antigen on a cancer cell, leading to downregulation of oncogene signaling, or to flag tumor cells for destruction by the immune system.8 The anti–human epidermal growth factor receptor 2 (HER2) monoclonal antibodies trastuzumab (Herceptin) and pertuzumab (Perjeta) have drastically improved outcomes for HER2-positive breast cancer, which accounts for 15% to 25% of patients with breast cancer.9 All patients with breast cancer should undergo testing for HER2 overexpression.10 Trastuzumab binds to HER2 on tumor cells, leading to internalization and down-regulation of HER2, which is a progrowth stimulator. Trastuzumab is not as effective in treating advanced gastroesophageal cancer with HER2 overexpression, offering only a 12% overall response rate.11 Cetuximab (Erbitux) is another monoclonal antibody used as targeted therapy; it binds to the epidermal growth factor receptor (EGFR), leading to downregulation of this potent growth modulator. Cetuximab and a similar anti-EGFR monoclonal antibody, panitumumab (Vectibix), are effective in treating metastatic colorectal cancer without mutations in the RAS gene because RAS mutations make tumor cells resistant to the effects of the EGFR blockade.12 Detailed testing for RAS mutations is necessary before choosing a chemotherapy regimen for metastatic colorectal cancer.

SMALL MOLECULE INHIBITORS

Small molecule inhibitors impede a vast number of targets to slow or kill tumor cells. The majority target protein kinases that are highly active progrowth signaling initiators present in all cells and are exploited by many cancers. Examples of protein kinases targeted by small molecule inhibitors include the EGFR, anaplastic lymphoma kinase, and HER2. These protein kinases are also expressed across healthy tissues, so small molecule inhibitors also have systemic effects.

Many small molecule inhibitors, such as sunitinib (Sutent), are not considered targeted therapy. This drug targets multiple, wild-type intracellular kinases and does not require testing for mutations in the tyrosine kinases that it targets (e.g., vascular endothelial growth factors).13 Alternatively, osimertinib (Tagrisso) is used only in advanced non–small cell lung cancer that contains an activating mutation in the EGFR.14

Small molecule inhibitors illustrate the ways in which the benefits of targeted therapies can range from transformational to marginal, depending on the cancer and target. For instance, when treated with osimertinib, patients with metastatic EGFR-mutated lung cancer live a median of 39 months,14 which is more than double the survival compared with similar patients treated with the first EGFR inhibitor, erlotinib (Tarceva), between 2007 and 2011.15 Similarly, patients with advanced lung cancer possessing an anaplastic lymphoma kinase fusion have a 79% response rate to the drug alectinib (Alecensa).16 At the other end of the spectrum are drugs with modest or absent survival gains. Olaparib (Lynparza) and other poly- (adenosine diphosphate-ribose) polymerase inhibitors induce double-strand DNA breaks that cannot be repaired in breast cancer gene–mutated tumors, a mechanism termed synthetic lethality. Poly- (adenosine diphosphate-ribose) polymerase inhibitors have yet to demonstrate any improvements in survival in breast cancer gene–mutated ovarian cancer.17

ANTIBODY-DRUG CONJUGATES

Antibody-drug conjugates use a monoclonal antibody bound to a cytotoxic chemotherapy molecule by a peptide linker. This allows cytotoxic therapy to be delivered directly to, and cleaved inside, a tumor cell. When tumor cells undergo apoptosis, cytotoxic chemotherapy is released, killing additional nearby tumor cells. Normal host cells in the vicinity of the tumor may also be killed; this is called the bystander effect. Additionally, amounts of the cytotoxic agent can be released prematurely into the systemic circulation. Thus, antibody-drug conjugates can still result in systemic adverse effects such as fatigue, nausea, peripheral neuropathy, and thrombocytopenia.18

IMMUNOTHERAPY

Immunotherapy is a broad term that includes monoclonal antibodies against cytotoxic T-lymphocyte–associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1), or programmed cell death ligand 1 (PD-L1), which are capable of activating the adaptive immune system against tumor cells. These immunotherapy molecules inhibit negative immune regulation and, therefore, enhance antitumor immune responses.

Immunotherapy has earned broad use. As of 2018, 43.6% of patients with cancer would be eligible for one of these drugs. Such immune checkpoint inhibitors are most commonly used in a nontargeted sense; for example, all patients with metastatic non–small cell lung cancer are likely eligible for this therapy.19 PD-L1 expression by tumor cells or tumor-infiltrating immune cells may help predict which tumors are likely to respond to immunotherapy.20 For example, the PD-L1 monoclonal antibody atezolizumab (Tecentriq), when combined with two cytotoxic chemotherapy drugs, improves survival by 10 months compared with placebo plus cytotoxic chemotherapy in patients with triple negative breast cancer and PD-L1 positive tumor–infiltrating immune cells; however, it did not improve survival in patients who had negative PD-L1 staining.21 PD-L1 is not a reliable predictor of response in many types of cancer, including metastatic non–small cell lung cancer, a disease in which immunotherapy is broadly used.22

Testing Cancer for Actionable Mutations

Specific testing of tumors for targetable alterations is critical in many advanced cancers. The initial therapy prescribed for metastatic non–small cell lung cancer will likely be an oral small molecule inhibitor if alterations in EGFR, anaplastic lymphoma kinase, receptor tyrosine kinase encoded by gene ROS1 (ROS1), or B-raf proto-oncogene (BRAF) are detected.15,23 If an elevated expression of PD-L1 is found in the tumor, immunotherapy may be used alone or in combination with cytotoxic chemotherapy.24

The initial therapy for metastatic colorectal cancer hinges on whether mutations in RAS are found (unlikely to benefit from EGFR monoclonal antibodies) and whether the tumor has mismatch repair deficiency, indicating a likely diagnosis of the hereditary Lynch syndrome and response to immunotherapy.25,26 Additionally, metastatic colorectal cancer that possesses a BRAF mutation is more aggressive, and therapy including a BRAF small molecule inhibitor should be considered.27 Other cancers for which genomic testing is critical to choosing chemotherapy include acute leukemias and metastatic bladder, breast, melanoma, ovarian, pancreatic, and prostate cancers.

Adverse Events of Targeted Therapy

Targeted oncology medications expose patients to unique toxicities, unlike the somewhat predictable adverse effects of cytotoxic chemotherapies (Table 1). One such example is ponatinib (Iclusig), which is used for the treatment of more aggressive forms of chronic myelogenous leukemia. Between 20% and 30% of patients with chronic myelogenous leukemia treated with ponatinib will experience a serious adverse event such as a heart attack, stroke, or peripheral vascular event. Taking ponatinib is linked to a 1% rate of death from these events.28 This led the FDA to briefly remove ponatinib from the market and to rerelease it with a boxed warning and reduced starting dose.29 The increasing tendency of the FDA to approve targeted cancer therapies rapidly based on early, nonrandomized evidence, as occurred with ponatinib, means that future drugs may offer unanticipated and severe adverse events.30 Patients taking ponatinib should also be taking low-dose aspirin if no contraindications exist.28

Table 2 lists possible interactions between targeted oncology medications and drugs prescribed frequently by primary care physicians. A common example is acid suppression with proton pump inhibitors when oral chemotherapeutic agents require an acidic environment for absorption.26,3133 Solutions may include switching to histamine H2 receptor antagonists or spacing out medication dosing. Cytochrome P450, family 3A (CYP3A) inhibitors and inducers such as azoles, amiodarone, macrolide antibiotics, nondihydropyridine calcium channel blockers, antiepileptics, and antiviral medications may also lead to drug interactions.33 Often, dose reductions in the chemotherapy agent are enough to reduce the CYP3 interactions. Some oral chemotherapy drugs interact with warfarin (Coumadin), requiring closer international normalized ratio monitoring. Safe medication reconciliation requires that the oncologist, pharmacist, and primary care physician work together closely and maintain open lines of communication.

TABLE 2.

Common Drug Interactions of Targeted Oncology Therapeutics

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CYP3A inhibitors/inducers
Entrectinib (Rozlytrek)
Erdafitinib (Balversa)
Gefitinib (Iressa)
Ibrutinib (Imbruvica)
Imatinib (Gleevec)
Lapatinib (Tykerb)
Larotrectinib (Vitrakvi)
Midostaurin (Rydapt)
Olaparib (Lynparza) and other poly- (adenosine diphosphate-ribose) polymerase inhibitors
Osimertinib (Tagrisso)
Ponatinib (Iclusig)
Venetoclax (Venclexta)
Histamine H2 blockers/PPIs
Bosutinib (Bosulif; avoid PPIs)
Crizotinib (Xalkori)
Dabrafenib
Dasatinib (Sprycel; avoid PPIs)
Erlotinib (avoid PPIs)
Gefitinib
Nilotinib (Tasigna; avoid PPIs)
Ponatinib (avoid PPIs)
Warfarin (Coumadin)
Dabrafenib (Tafinlar)
Erlotinib (Tarceva)
Gefitinib
Imatinib
Vemurafenib (Zelboraf)
Venetoclax

CYP3A = cytochrome P450, family 3A; PPI = proton pump inhibitor.

Immunotherapy is another group of targeted therapies for which understanding the unique and unpredictable toxicities is crucial.33 Patients taking PD-1/PD-L1 or CTLA-4 monoclonal antibodies may develop autoimmune reactions of the skin (rash: 13% to 24% with pembrolizumab [Keytruda], up to 50% with ipilimumab [Yervoy]), thyroid, and other endocrine organs (hypo- or hyperthyroidism: 9% to 18% with pembrolizumab or nivolumab [Opdivo]), and more rarely gut (colitis), liver (hepatitis), lungs (pneumonitis), heart (myocarditis), brain (encephalitis), or other organs.3436 Severe colitis requiring permanent discontinuation of immunotherapy and high-dose steroid treatment occurs in 3% to 6% of patients taking a combination of nivolumab and ipilimumab.36 Severe pneumonitis occurs in 3.2% of patients with lung cancer who are being treated with pembrolizumab.35

Immunotherapy-related adverse events may range in severity from transient to fatal and can occur at any point after receiving an immune checkpoint therapy.37 Delay in diagnosis and initiation of proper treatment—especially in cases of pneumonitis, colitis, and myocarditis—can be fatal. Evidence about which patients are likely to develop these toxicities is emerging, but patients with preexisting autoimmune conditions are at higher risk and are nearly universally excluded from immunotherapy candidacy.38 Patient and caregiver education and physician recognition of these toxicities are crucial because patients need to begin steroid therapy immediately.37

Future Directions

Targeted oncology may be moving toward a tumor-agnostic approach, in which treatments are chosen based on specific mutations in a tumor rather than the organ of origin.39 Pembrolizumab is approved for all cancers that have mismatch repair deficiency, a biomarker theorized to confer sensitivity to immune unmasking.40 The neurotrophin receptor kinase inhibitors entrectinib (Rozlytrek) and larotrectinib (Vitrakvi) are approved for all solid tumors that contain neurotrophin receptor kinase fusions.41 Such a tumor-agnostic approach has not always succeeded; vemurafenib (Zelboraf) works well for BRAF-mutated melanoma and colorectal cancer but appears ineffective in BRAF-mutated myeloma.42 It remains uncertain what effect tumor-agnostic drug approvals will have on national or global cancer outcomes.43

Financial Toxicity of Targeted Therapy

Increasingly, financial toxicity is recognized as a very real adverse effect of targeted cancer therapy. Oral cancer therapies offer the convenience of pills that can be taken at home, but they often place financial burdens on patients because of out-of-pocket costs at the pharmacy. In 2020, the average out-of-pocket cost to a patient for a course of oral cancer therapy was estimated at $5,663.44 According to one large analysis, 20% of patients with cancer take less medication than prescribed, 19% partially fill oral cancer therapy prescriptions, and 24% avoid filling a prescription at all.45 Many patients in this study reported spending less money on food, leisure, and clothing.45 Approximately 2% of patients will declare bankruptcy during their treatment; those with advanced disease are more likely to declare bankruptcy.46 Bankruptcy during cancer treatment increases the risk of death.46 Beyond financial toxicity to the individual patient, the effects of targeted oncology on escalating health care costs are significant. Immunotherapy is not cost-effective in some studies,47 and testing of advanced cancers using next-generation sequencing assays may substantially increase the cost of care without meaningfully affecting survival.48 Primary care physicians can help patients by assessing for financial toxicity and by offering suggestions such as drug company assistance, charity care, and social work resources to make cancer treatment more affordable.

This article updates a previous article on this topic by Gerber.49

Data Sources: A PubMed search was completed in Clinical Queries using the key terms precision oncology, metastatic non–small cell lung cancer, BRCA, breast cancer, ovarian cancer, HER2-positive breast cancers; locally advanced and metastatic melanoma, metastatic colorectal cancer, chronic myeloid leukemia, NTRK fusion solid tumors, microsatellite unstable solid tumors, tumor agnostic, oral cancer drug interactions, immunotherapy toxicity, and financial toxicity. Also searched were the National Comprehensive Cancer Network guidelines, UpToDate, Essential Evidence Plus, and the U.S. Food and Drug Administration website. Search dates: March 7 and October 13, 2020.

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  11. Bang Y-J, Van Cutsem E, Feyereislova A, et al.; ToGA Trial Investigators. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastrooesophageal junction cancer (ToGA) [published correction appears in Lancet. 2010;376(9749):1302]. Lancet. 2010;376(9742):687-697.

  12. Qin S, Li J, Wang L, et al. Efficacy and tolerability of first-line cetuximab plus leucovorin, fluorouracil, and oxaliplatin (FOLFOX-4) versus FOLFOX-4 in patients with RAS wild-type metastatic colorectal cancer: the open-label, randomized, phase III TAILOR trial. J Clin Oncol. 2018;36(30):3031-3039.

  13. Motzer RJ, Hutson TE, Cella D, et al. Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med. 2013;369(8):722-731.

  14. Ramalingam SS, Vansteenkiste J, Planchard D, et al.; FLAURA Investigators. Overall survival with osimertinib in untreated, EGFR-mutated advanced NSCLC. N Engl J Med. 2020;382(1):41-50.

  15. Rosell R, Carcereny E, Gervais R, et al.; Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia Toracica. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC). Lancet Oncol. 2012;13(3):239-246.

  16. Alecensa (alectinib) [package insert]. Chugai Pharmaceutical; 2017. Updated June 2018. Accessed May 1, 2020. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/208434s004lbl.pdf

  17. Wiggans AJ, Cass GK, Bryant A, et al. Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer. Cochrane Database Syst Rev. 2015(5):CD007929.

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  20. Yarchoan M, Albacker LA, Hopkins AC, et al. PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers. JCI Insight. 2019;4(6):e126908.

  21. Schmid P, Adams S, Rugo HS, et al.; IMpassion130 Trial Investigators. Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer. N Engl J Med. 2018;379(22):2108-2121.

  22. Paz-Ares L, Luft A, Vicente D, et al.; KEYNOTE-407 Investigators. Pembrolizumab plus chemotherapy for squamous non-small-cell lung cancer. N Engl J Med. 2018;379(21):2040-2051.

  23. National Comprehensive Cancer Network. NCCN guidelines in oncology. Non small cell lung cancer version 8. 2020. Accessed October 13, 2020. https://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf

  24. Mok TSK, Wu Y-L, Kudaba I, et al.; KEYNOTE-042 Investigators. Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042). Lancet. 2019;393(10183):1819-1830.

  25. National Comprehensive Cancer Network. NCCN guidelines in oncology. Colon cancer version 4. 2020. Accessed October 13, 2020. https://www.nccn.org/professionals/physician_gls/pdf/colon.pdf

  26. Iclusig (ponatinib) [package insert]. Ariad Pharmaceuticals; 2012. Accessed May 9, 2020. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203469lbl.pdf

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