| Avoid | | | | |
| < 3 years or 10 kg (22 lb) | Darunavir (Prezista) | Seizures, death | Strong | Very low |
| < 6 years | Diphenoxylate/atropine (Lomotil) | Respiratory depression, death | Strong | Moderate |
| Linaclotide (Linzess) | Death from dehydration | Weak | Very low |
| Plecanatide (Trulance) | Death from dehydration | Weak | Very low |
| < 10 years or 50 kg (110 lb) | Lindane | Seizure, spasm | Moderate | Low |
| All children | Indinavir (Crixivan) | Nephrolithiasis | Strong | High |
| Paregoric | Gasping syndrome, seizures, central nervous system depression, hypoglycemia | Strong | High |
| Propofol (Diprivan; avoid more than 4 mg per kg per hour for > 48 hours) | Infusion syndrome | Strong | Moderate |
| Caution | | | | |
| < 6 years | Valproic acid | Pancreatitis, fatal hepatotoxicity | Strong | High |
| < 8 years | Tetracyclines | Enamel hypoplasia, tooth discoloration | Strong | High |
| All children | Camphor | Seizures | Weak | Low |
| Dopamine antagonists* | Dystonia, respiratory depression, death | Strong | Moderate |
| Lamotrigine (Lamictal) | Serious skin rashes | Strong | High |
| Meperidine (Demerol) | Respiratory depression | Strong | High |
| Olanzapine (Zyprexa; concern for use > 24 weeks) | Metabolic syndrome | Strong | High |
| Opium tincture | Respiratory depression | Strong | High |
| Salicylates (if suspicion of viral illness) | Reye syndrome | Weak | Very low |
| Tramadol | Respiratory depression | Weak | Low |
