Infection	Adults	Children
Acute bacterial rhinosinusitis	First-line treatment: Amoxicillin/clavulanate (Augmentin), 500 mg orally every eight hours or 875 mg every 12 hours for five to seven days Penicillin allergy: Doxycycline, 100 mg orally twice per day for five to seven days Cefixime (Suprax), 400 mg orally per day for five to seven days	First-line treatment: Amoxicillin/clavulanate, 45 mg amoxicillin per kg per day orally, divided every 12 hours for 10 to 14 days Penicillin allergy: Cefpodoxime, 10 mg per kg orally per day for 10 to 14 days Cefdinir , 14 mg per kg per day orally, divided in one to two doses for 10 to 14 days
Acute otitis media	First-line treatment: Amoxicillin/clavulanate, 875 mg orally twice per day or 500 mg orally every eight hours for five to 10 days* Penicillin allergy: Cefdinir, 300 mg orally twice per day or 600 mg orally per day for five to 10 days* Cefpodoxime, 200 mg orally twice per day for five to 10 days* Doxycycline, 100 mg twice per day for five to 10 days* Azithromycin (Zithromax), 500 mg orally on day 1 then 250 mg orally per day on days 2 to 5	First-line treatment: Amoxicillin, 80 to 90 mg per kg per day orally divided every 12 hours for five to 10 days† Penicillin allergy: Cefdinir, 14 mg per kg per day orally divided in one to two doses for five to 10 days† Cefpodoxime, 10 mg per kg per day divided in two doses for five to 10 days† Second-line treatment (for children who have taken amoxicillin within the past 30 days, with concurrent purulent conjunctivitis, with a history of recurrent acute otitis media, unresponsive to amoxicillin, or with no improvement after 48 to 72 hours of initial treatment with amoxicillin): Amoxicillin/clavulanate, 90 mg per kg per day of amoxicillin with 6.4 mg per kg per day of clavulanate in two divided doses for five to 10 days†
Group A beta-hemolytic streptococcal pharyngitis	First-line treatment: Penicillin V, 250 mg orally four times per day or 500 mg orally twice per day for 10 days Amoxicillin, 1,000 mg orally per day or 500 mg orally twice per day for 10 days Penicillin G benzathine, 1,200,000 U intramuscularly Penicillin allergy: Cephalexin , 500 mg orally twice per day for 10 days Clindamycin, 300 mg orally three times per day for 10 days Azithromycin, 500 mg orally per day for five days	First-line treatment: Penicillin V, 250 mg orally two to three times per day for 10 days in children; 250 mg orally four times per day or 500 mg orally twice per day for 10 days in adolescents Amoxicillin, 50 mg per kg orally per day (maximum: 1,000 mg) or 25 mg per kg orally (maximum: 500 mg) twice per day for 10 days Penicillin G benzathine, (< 27 kg) 600,000 U intramuscularly, (≥ 27 kg) 1,200,000 U intramuscularly Penicillin allergy: Cephalexin, 20 mg per kg per dose orally (maximum: 500 mg) twice per day for 10 days Clindamycin, 7 mg per kg per dose orally (maximum: 300 mg) three times per day for 10 days Azithromycin, 12 mg per kg per dose orally (maximum: 500 mg) per day for five days