Details for This Review

Study Population: Adults in any care setting (e.g., hospital, outpatient, long-term care facility, home care) who presented with pressure ulcers, leg ulcers (venous, arterial, or mixed etiology), and diabetic foot ulcers

Efficacy End Points: Primary outcomes: complete wound and ulcer healing, time to complete wound healing; secondary outcomes: health-related quality of life; pain; wound recurrence rate; change in wound size and area

Harm End Points: Adverse events

Narrative: Chronic wounds are defined as wounds that do not heal as expected. They are extremely common worldwide and are often related to underlying disease (e.g., diabetes mellitus, vascular disease), can decrease quality of life, and are costly to manage.¹ Some evidence suggests that application of hyaluronic acid, most commonly in an aqueous gel formulation, to chronic wounds may promote healing during the inflammation and granulation phases of wound healing.² Hyaluronic acid is proposed to maintain a moist wound environment that helps cell migration in the wound bed. This process is thought to reduce scarring and fibrosis, improve angiogenesis, and reduce overall inflammation.^2–5