Am Fam Physician. 2024;110(1):21
What are first-line options for the treatment of painful diabetic peripheral neuropathy?
Duloxetine (Cymbalta) and pregabalin (Lyrica) are first-line agents for the treatment of painful diabetic peripheral neuropathy; amitriptyline and gabapentin are considered alternative first-line agents because they have more adverse effects.
Is a high-dose recombinant influenza vaccine (FluBlok) more effective than a standard-dose, egg-based vaccine in adults 50 to 64 years of age?
A U.S.-based cluster randomized controlled trial of 1.6 million participants found that high-dose, egg-free recombinant vaccines offer a very small absolute reduction in the risk of influenza but have no effect on hospitalization. The recombinant vaccines may be less likely to have a mismatch due to antigenic drift from year to year, but this has not been proven because the match for these vaccines was relatively poor during the study years.
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