Am Fam Physician. 2024;110(1):85-86
Author disclosure: No relevant financial relationships.
| Test | Indication | Population | Cost* |
|---|---|---|---|
| Modified two-tiered serodiagnostic testing algorithm | Suspected acute phase or early disseminated Lyme disease | Patients with a moderate or high pretest probability for Lyme disease | $34.06 |
Lyme disease is the most common vector-borne illness, with more than 476,000 cases annually in the United States and can be challenging to diagnose.1 The presence of erythema migrans is considered diagnostic in patients who live in or have recently traveled to an endemic area. However, serologic testing is recommended if the cause of the skin lesion is unknown and antibiotics have not been administered. Serologic testing is also recommended for early disseminated and late-stage Lyme disease.2
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