Which subset of men who have sex with men should be offered preexposure prophylaxis?

Preexposure prophylaxis (PrEP) is recommended for men who have sex with men who have increased risk of HIV infection, defined as anal sex within the past 6 months and one of the following: a sex partner with HIV infection (especially with an unknown or detectable viral load), history of bacterial sexually transmitted infection in the past 6 months, or inconsistent condom use with partners of unknown HIV status.

Preventive Care for Men Who Have Sex With Men; April 2024

Does treatment with monoclonal antibody therapy that targets amyloid improve patient outcomes for those living with Alzheimer disease?

According to a meta-analysis of 19 studies, amyloid-targeting antibodies for the treatment of Alzheimer disease have not demonstrated clinically meaningful benefits. These therapies are associated with concerning risks of harm, most notably cerebral hemorrhage identified in imaging studies (number needed to harm = 13). So far, the balance of risk vs. benefit demonstrated does not justify the use of these costly drugs (more than $20,000 annually).