Am Fam Physician. 2025;111(1):92-93
An audio version of this AFP Practice Guideline is available on the AAFP audio app.
Author disclosure: No relevant financial relationships.
KEY POINTS FOR PRACTICE
• Positioning patients in a semi-Fowler position with the head and trunk raised may increase intubation success and decrease aspiration risk.
• Preoxygenation with high-flow nasal oxygen is effective and can be used throughout intubation. With severe hypoxemia, noninvasive positive pressure ventilation is recommended for preoxygenation.
• Before rapid sequence intubation, paralysis with a neuromuscular blocking agent (ie, succinylcholine or rocuronium) is recommended to increase intubation success and reduce vomiting risk.
From the AFP Editors
Emergency airway management is high-risk and involves multiple decisions. Rapid sequence intubation, which usually occurs after administration of a sedative-hypnotic agent and a neuromuscular blocking agent in rapid succession, should optimize the chance of successful intubation while reducing peri-intubation risks such as aspiration or hypotension. The Society of Critical Care Medicine developed guidelines to optimize rapid sequence intubation.
POSITIONING
Simulation studies suggest that sitting a patient up from the traditional supine position to a semi-Fowler position (ie, head and trunk raised) before intubation decreases aspiration risk, increases lung volumes, and improves intubation success through better views. The guideline suggests semi-Fowler positioning based on very low-quality evidence from conflicting studies. Although simulation and observational studies clearly demonstrate improved first-pass intubation success with semi-Fowler positioning compared with the supine position, the few randomized trials demonstrated no difference between the two positions.
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