Website maintenance is scheduled for Saturday, January 18, and Sunday, January 19. Short disruptions will occur during these days.

brand logo

STEPHEN R. FOSTER, MD, AND KODI M. LIDDELL, PharmD, BCPS, BCACP

Am Fam Physician. 2025;111(1):87-88

Author disclosure: No relevant financial relationships.
DrugDosageDose formCost*
Gepirone (Exxua)18.2 mg once daily; increasing as needed to a maximum dosage of 72.6 mg daily18.2-mg, 36.3-mg, 54.5-mg, and 72.6-mg tablets$699

Gepirone (Exxua) is used to treat major depressive disorder in adults. Although the mechanism of action is not fully understood, it is thought to work through selective agonist activity at 5-HT1A receptors. This differentiates gepirone from mainstays of therapy such as selective serotonin reuptake inhibitors (SSRIs).1

SAFETY

Already a member/subscriber?  Log In

Subscribe

From $165
  • Immediate, unlimited access to all AFP content
  • More than 130 CME credits/year
  • AAFP app access
  • Print delivery available
Subscribe

Issue Access

$59.95
  • Immediate, unlimited access to this issue's content
  • CME credits
  • AAFP app access
  • Print delivery available
Purchase Access:  Learn More

STEPS new drug reviews cover Safety, Tolerability, Effectiveness, Price, and Simplicity. Each independent review is provided by authors who have no financial association with the drug manufacturer.

This series is coordinated by Allen F. Shaughnessy, PharmD, assistant medical editor.

A collection of STEPS published in AFP is available at https://www.aafp.org/afp/steps.

Continue Reading

More in AFP

Copyright © 2025 by the American Academy of Family Physicians.

This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP.  See permissions for copyright questions and/or permission requests.

Copyright © 2025 American Academy of Family Physicians. All Rights Reserved.