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Am Fam Physician. 2025;111(2):171-172

Author disclosure: No relevant financial relationships.

The MI-Heart Ceramides test is used to determine the risk of adverse cardiovascular events. It assesses various plasma ceramides, a type of complex lipid. There are many different types of ceramides in the body resulting from unstable atherosclerotic plaques. When elevated, ceramides are associated with major adverse cardiovascular events (MACE). The MI-Heart Ceramides test has not been approved by the US Food and Drug Administration.

TestIndicationPopulationCost*
MI-Heart
Ceramides test
Stratify the risk of major adverse cardiovascular events within the next 1–5 yearsAdults 18 years and older with or without existing cardiovascular disease$180
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This series is coordinated by Natasha Pyzocha, DO, contributing editor.

A collection of Diagnostic Tests published in AFP is available at https://www.aafp.org/afp/diagnostic.

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