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These key learning points summarize the consensus- and evidence-based recommendations included in this edition. The sources listed here for each statement recommend that physicians perform or implement these actions directly in a clinical setting.

1. Screen for depression in the general adult population, including pregnant and postpartum women, when adequate systems are in place for accurate diagnosis, effective treatment, and appropriate follow-up.

Strength of Evidence: SORT B
Source: U.S. Preventive Services Task Force, reference 11
Website: https://www.aafp.org/pubs/afp/issues/2016/0815/od1.html

2. Screen patients with depressive symptoms for current or past symptoms of hypomania or mania at the initial visit and at subsequent visits if there is a poor response to treatment.

Strength of Evidence: SORT B
Source: Lancet, reference 51
Website: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31544-0/fulltext

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